- 作者：Walter Masson ; walter.masson@hospitalitaliano.org.ar" class="auth_mail" title="E-mail the corresponding author ; Daniel Siniawski ; Martí ; n Lobo ; Graciela Molinero ; Melina Huerí ; n
- 关键词：Triglycerides ; High density lipoprotein cholesterol ; Insulin resistance ; Carotid plaque ; Postmenopause
- 刊名：Endocrinología y Nutrición (English Edition)
- 出版年：2016
- 出版时间：August-September 2016
- 年：2016
- 卷：63
- 期：7
- 页码：327-332
- 全文大小：710 K
Patients and methods
Women (last menstrual period ≥ 2 years) in primary prevention up to 65 years of age were recruited. Association between the triglyceride/HDL cholesterol (HDL-C) ratio and presence of carotid plaque, assessed by ultrasonography, was analyzed. ROC analysis was performed, determining the precision of this ratio to detect carotid plaque.
Results
A total of 332 women (age 57 ± 5 years) were recruited. Triglyceride/HDL-C ratio was 2.35 ± 1.6. Prevalence of carotid plaque was 29%. Women with carotid plaque had higher triglyceride/HDL-C ratios (3.33 ± 1.96 vs. 2.1 ± 1.2, p < 0.001) than women with no carotid plaque. A positive relationship was seen between quintiles of this ratio and prevalence of carotid plaque (p < 0.001). Regardless of other risk factors, women with higher triglyceride/HDL-C ratios were more likely to have carotid plaque (odds ratio 1.47, 95% confidence interval 1.20–1.79, p < 0.001). The area under the curve of the triglyceride/HDL-C ratio to detect carotid plaque was 0.71 (95% confidence interval 0.65 to 0.76), and the optimal cut-off point was 2.04.
Conclusions
In postmenopausal women in primary prevention, insulin resistance, estimated from the triglyceride/HDL-C ratio, was independently associated to a greater probability of carotid plaque. A value of such ratio greater than 2 may be used for assessing cardiovascular risk in this particular group of women.