Direct synthesis of nitriles from aldehydes with hydroxylamine-O-sulfonic acid in acidic water
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- 作者：Dylan J. Quinn ; Graham J. Haun ; Gustavo Moura-Letts ; moura-letts@rowan.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nitrile synthesis ; Hydroxylamine-O-sulfonic acid ; Nitrogen transfer reagents ; Diaziridines
- 刊名：Tetrahedron Letters
- 出版年：2016
- 出版时间：24 August 2016
- 年：2016
- 卷：57
- 期：34
- 页码：3844-3847
- 全文大小：3289 K
文摘
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Direct synthesis of nitriles from aromatic and aliphatic aldehydes.
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Novel approach to the synthesis of nitriles without metals or complex reagents.
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Large scope of aromatic and aliphatic aldehydes provide respective nitriles in very high yields.
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Reaction efficiency and robustness allows for isolation of nitriles without purification.