Ketogenic diet does not change NKCC1 and KCC2 expression in rat hippocampus

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• 作者：Gisela  ; Gó ; mez-Lirap> ;   ; p>p>ggomez@fisio.cinvestav.mxp> ; Julieta Griselda  ; Mendoza-Torreblancap> ;   ; p>p>julietamt14@hotmail.com.mxp> ; Leticia  ; Granados-Rojas  ; p> ;   ; p>p>lgranados_2000@yahoo.com.mxp>
• 关键词：Ketogenic diet ; NKCC1 ; KCC2 ; Optical fractionator ; Hippocampus ; Rat
• 刊名：Epilepsy Research
• 出版年：2011
• 出版时间：September 2011
• 年：2011
• 卷：96
• 期：1-2
• 页码：166-171
• 全文大小：329 K

文摘

Summary

In control rats, we examined the effects of ketogenic diet on NKCC1 and KCC2 expression levels in hippocampus. Neither the number of NKCC1 immunoreactive cells nor the intensity of labeling of KCC2 was found to modify in hippocampus of the rats after ketogenic diet treatment. These results indicate that ketogenic diet by itself does not modify the expression of these cation chloride cotransporters.