Effect of nitrofurans and NO generators on biofilm formation by Pseudomonas aeruginosa
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- 作者：Julia Zaitseva ; Vladimir Granik ; Alex ; r Belik ; Olga Koksharova ; Inessa Khmel
- 关键词：Biofilms ; Nitrofurans ; NO ; NO donors ; Pseudomonas aeruginosa ; Burkholderia cenocepacia
- 刊名：Research in Microbiology
- 出版年：2009
- 出版时间：June 2009
- 年：2009
- 卷：160
- 期：5
- 页码：353-357
- 全文大小：370 K
文摘
Antibacterial drugs in the nitrofuran series, such as nitrofurazone, furazidin, nitrofurantoin and nifuroxazide, as well as the nitric oxide generators sodium nitroprusside and isosorbide mononitrate in concentrations that do not suppress bacterial growth, were shown to increase the capacity of pathogenic bacteria Pseudomonas aeruginosa PAO1 and Burkholderia cenocepacia 370 to form biofilms. At 25–100 μg/ml, nitrofurans 2–2.5-fold enhanced biofilm formation of P. aeruginosa PAO1, and NO donors 3–6-fold. For B. cenocepacia 370, the enhancement was 2–5-fold (nitrofurans) and 4.5-fold (sodium nitroprusside), respectively.