Dissecting the molecular mechanisms that impair stress granule formation in aging cells

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• 作者：Ossama Moujaber^a ; ¹ ; Hicham Mahboubi^a ; ¹ ; Mohamed Kodiha^a ; Manuella Bouttier^a ; Klaudia Bednarz^a ; Ragini Bakshi^a ; John White^a ; Louise Larose^b ; Iné ; s Colmegna^c ; Ursula Stochaj^a ; ^{ursula.stochaj@mcgill.ca}
• 关键词：CReP ; constitutive repressor of eIF2α phosphorylation ; HDAC ; histone/protein deacetylase ; SA-β-galactosidase ; senescence-associated β-galactosidase ; SG ; stress granule
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1864
• 期：3
• 页码：475-486
• 全文大小：3184 K
• 卷排序：1864

文摘

Stress granule formation is evaluated in two distinct models of cellular senescence. Aging interferes with the formation of cytoplasmic stress granules. Cellular senescence depletes stress granule nucleating proteins. Aging alters cell signaling involved in granule assembly.