Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules

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• 作者：Elda Grabocka¹ ; ² ; Dafna Bar-Sagi¹ ; ³ ; ^{dafna.bar-sagi@nyumc.org}
• 关键词：cancer ; KRAS ; stress granules ; prostaglandins
• 刊名：Cell
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：167
• 期：7
• 页码：1803-1813.e12
• 全文大小：4962 K
• 卷排序：167

文摘

Stress granules (SGs) are markedly elevated in mutant KRAS cells and tumors Mutant KRAS upregulates SGs by stimulating the production of 15-d-PGJ2 15-d-PGJ2 secretion by mutant KRAS cells enables paracrine upregulation of SGs Mutant KRAS-dependent upregulation of SGs confers resistance to stress stimuli