Personalized approaches to active immunotherapy in cancer
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- 作者：Eran Ophira ; Sara Bobissea ; George Coukosa ; c ; Alexandre Hararia ; b ; Lana E. Kandalafta ; b ; c ; Lana.Kandalaft@chuv.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：TAA ; tumor associated antigen ; HPV ; human papilloma virus ; DC ; dendritic cell ; CTL ; cytotoxic T cell ; TGF-β ; transforming-growth-factor-β ; MDSC ; myeloid-derived-supressor-cells ; CT ; cancer/testis ; Gp100 ; glycoprotein 100 ; MS ; mass spectrometry ; NGS ; next-generation sequencing ; GM-CSF ; granulocyte-macrophage colony-stimulating factor ; PAP ; prostatic acid phosphatase ; TIL. ; tumor infiltrating lymphocytes ; CLL ; chronic lymphocytic leukemia ; IFN-γ ; interferon-gamma ; BCG ; bacille Calmette&ndash ; Gu&ea
- 刊名：Biochimica et Biophysica Acta (BBA)-Reviews on Cancer
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：1865
- 期：1
- 页码：72-82
- 全文大小：794 K
文摘
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Neo-antigens are mutated tumor antigens, mostly specific for each patient.
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Recent technical advancement enabled personalized vaccines that target neo-antigens.
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Autologous tumor cells or tumor-pulsed DCs can be used for personalized vaccination.
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Autologous tumor vaccines may provide the full repertoire of tumor antigens.
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Combination strategies could be the key for effective personalized vaccination.