Tumor-associated macrophages: Potential therapeutic targets for anti-cancer therapy
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- 作者：Yoshihiro Komohara ; ycomo@kumamoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yukio Fujiwara ; Koji Ohnishi ; Motohiro Takeya
- 关键词：bFGF ; basic fibroblast growth factor ; CAF ; cancer-associated fibroblast ; CCL2/MCP1 ; chemokine ligand 2 ; CCR2 ; chemokine (C&ndash ; C motif) receptor 2 ; COX2 ; cyclooxygenase 2 ; CSC ; cancer stem-like cells ; CSF-1 ; colony stimulating factor 1 ; CTLA4 ; cytotoxic T lymphocyte antigen 4 ; CXCL ; chemokine (C&ndash ; X&ndash ; C motif) ligand ; EGFR ; epidermal growth factor receptor ; FRβ ; Folate receptor beta ; GM-CSF ; granulocyte macrophage colony stimulating factor ; HB-EGF ; heparin-binding EGF-like growth facto
- 刊名：Advanced Drug Delivery Reviews
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：99
- 期：part_PB
- 页码：180-185
- 全文大小：1068 K
文摘
The macrophage is known to be a multifunctional antigen presenting cells and playing a central role in inflammation. Macrophages infiltrate into malignant tumor tissues in high numbers (the so-called tumor-associated macrophages [TAMs]) and many studies over the past decade have demonstrated that macrophages have protumor functions and are closely related to tumor progression. It has been shown that protumor macrophages that have differentiated through interaction with tumor cells are involved in stem cell niches, immunosuppression, invasion, and metastasis. Consistent with these functions, studies using human tumor samples have demonstrated that a higher density of macrophages, especially macrophages with the M2 phenotype, is closely associated with worse clinical prognosis in many kinds of malignant tumors. Infiltrating TAMs themselves or polarization pathway of TAMs are considered as new therapeutic targets for the therapy of malignant tumors.