Grape-seed proanthocyanidins inhibit the lipopolysaccharide-induced inflammatory mediator expression in RAW264.7 macrophages by suppressing MAPK and NF-κb signal pathways
详细信息 查看全文
- 作者：Hongqian Chu1 ; Qiuqiong Tang1 ; Hongpeng Huang ; Weidong Hao ; whao@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xuetao Wei ; weixt1010@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Grape-seed proanthocyanidins ; Cytokines ; MAPK ; NF-κb
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：41
- 期：Complete
- 页码：159-166
- 全文大小：2011 K
文摘
- •
LPS was used to induced inflammatory reaction in RAW264.7 macrophages.
- •
Grape seed proanthocyanidins suppressed the mRNA level of inflammatory mediators.
- •
Grape seed proanthocyanidins suppressed the secretion of inflammatory mediators.
- •
GSPs treatment inhibited the nuclear factor-κB and MAPK signal pathways.