- 作者：Vergara-Galicia Jorge ; Jimenez-Ramirez Luis ¨¢ngel ; Tun-Suarez Adri¨¢n ; Aguirre-Crespo Francisco ; Salazar-G¨®mez Anuar ; Estrada-Soto Samuel ; Sierra-Ov ; o ¨¢ngel ; Hern ; ez-Nu?ez Emmanuel
- 关键词：Aortic ring ; Apium graveolens ; Medicinal plant ; Vasorelaxant
- 刊名：Asian Pacific Journal of Tropical Biomedicine
- 出版年：2013
- 出版时间：October, 2013
- 年：2013
- 卷：3
- 期：10
- 页码：776-779
- 全文大小：419 K
Objective
To investigate vasorelaxant effect of organic extracts from Apium graveolens (A. graveolens) which is a part of a group of plants subjected to pharmacological and phytochemical study with the purpose of offering it as an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive effects.Methods
An ex vivo method was employed to assess the vasorelaxant activity. This consisted of using rat aortic rings with and without endothelium precontracted with norepinephrine.
Results
All extracts caused concentration-dependent relaxation in precontracted aortic rings with and without endothelium; the most active extracts were Dichloromethane and Ethyl Acetate extracts from A. graveolens. These results suggested that secondary metabolites responsible for the vasorelaxant activity belong to a group of compounds of medium polarity. Also, our evidence showed that effect induced by dichloromethane and ethyl acetate extracts from A. graveolens is mediated probably by calcium antagonism.
Conclusions
A. graveolens represents an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive effects.