Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation
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- 作者：Vidhi Gaur1 ; 11 ; Timothy Connor1 ; 11 ; Andrew Sanigorski1 ; Sheree D. Martin1 ; Clinton R. Bruce2 ; Darren C. Henstridge3 ; Simon T. Bond1 ; Kevin A. McEwen1 ; Lyndal Kerr-Bayles1 ; Trent D. Ashton4 ; Cassandra Fleming4 ; Min Wu5 ; Lisa S. Pike Winer5 ; Denise Chen5 ; Gregg M. Hudson6 ; John W.R. Schwabe6 ; Keith Baar7 ; Mark A. Febbraio3 ; 8 ; Paul Gregorevic9 ; Frederick M. Pfeffer4 ; Ken R. Walder1 ; Mark Hargreaves10 ; Sean L. McGee1 ; 3 ; 12 ; sean.mcgee@deakin.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Skeletal muscle ; HDAC4 ; HDAC5 ; MEF2
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：13 September 2016
- 年：2016
- 卷：16
- 期：11
- 页码：2802-2810
- 全文大小：2871 K
文摘
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HDAC4/5 active-site mutants increase exercise-responsive genes and metabolism
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Scriptaid is a compound with similar phenotypic effects in vitro
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Acute Scriptaid administration in mice increases exercise-responsive genes
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Chronic Scriptaid administration reduces blood glucose and lipids in mice