Time to decompensated cirrhosis and hepatocellular carcinoma after an HBV or HCV notification: A population-based study

详细信息    查看全文

• 作者：Maryam Alavi¹ ; ^{msalehialavi@kirby.unsw.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Matthew G. Law¹ ; Jason Grebely¹ ; Janaki Amin¹ ; Behzad Hajarizadeh¹ ; Jacob George² ; Gregory J. Dore¹
• 关键词：HBV ; hepatitis B virus ; HCV ; hepatitis C virus ; DC ; decompensated cirrhosis ; HCC ; hepatocellular carcinoma ; DAA ; direct acting antiviral ; NSW ; New South Wales ; NCIMS ; Notifiable Conditions Information Management System ; NHR ; National HIV Registry ; APDC ; admitted patient data collection ; ICD-10-AM ; International Classification of Diseases-Australian Modification ; CCR ; Central Cancer Registry ; LHD ; local health district ; IQR ; interquartile range ; aOR ; adjusted odds ratio
• 刊名：Journal of Hepatology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：65
• 期：5
• 页码：879-887
• 全文大小：829 K

文摘

Delayed hepatitis B virus (HBV) or hepatitis C virus (HCV) diagnosis may increase risk of advanced liver disease complications, including decompensated cirrhosis (DC) and hepatocellular carcinoma (HCC). The aim of this study was to characterise “late hepatitis notification” among people with an HBV/HCV notification and advanced liver disease in New South Wales, Australia.

Methods

HBV/HCV notifications 1995–2012 were linked to cancer registry and hospital admissions. Late hepatitis notification was defined by a notification after, at the time, or within two years before DC/HCC diagnosis.

Results

HBV and HCV cohorts comprised 50,958 and 79,727 individuals, respectively. Among people with DC (n = 3869), late HBV notification declined from 64% (88/138) during 2001–2002 to 31% (46/149) in 2011–2012 (p <0.001), and late HCV notification declined from 52% (179/341) during 2001–2002 to 22% (134/605) in 2011–2012 (p <0.001). Among people with HCC (n = 1656), late HBV notification declined from 68% (59/87) during 2001–2002 to 29% (37/128) in 2011–2012 (p <0.001), and late HCV notification declined from 51% (40/79) during 2001–2002 to 17% (49/288) in 2011–2012 (p <0.001).

Conclusions

Despite significant declines in late hepatitis notification since early 2000s, efforts to enhance hepatitis screening, particularly for HBV, are required. Late hepatitis notification as described in this study could be used as a measure of population-level HBV/HCV screening.

Lay summary

Delayed hepatitis B virus (HBV) or hepatitis C virus (HCV) diagnosis may increase the risk of advanced liver disease complications, including decompensated cirrhosis (DC) and hepatocellular carcinoma (HCC). The aim of this study was to characterise “late hepatitis notification” among people with an HBV or HCV notification in New South Wales, Australia. Late hepatitis notifications have significantly declined since early 2000s; however, efforts to enhance hepatitis screening, particularly for HBV, are required. Late hepatitis notification as described in this study could be used as a measure of population-level HBV/HCV screening.