文摘
An investigation is detailed of the structure activity relationships (SAR) of two sulfone side chains of compound (?)-1a (SCH 900229), a potent, PS1-selective ¦Ã-secretase inhibitor and clinical candidate for the treatment of Alzheimer¡¯s disease. Specifically, 4-CF3 and 4-Br substituted arylsulfone analogs, (?)-1b and (?)-1c, are equipotent to compound (?)-1a. On the right hand side chain, linker size and terminal substituents of the pendant sulfone group are also investigated.