Changes in trabecular microarchitecture in postmenopausal women on bisphosphonate therapy

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• 作者：Susan L. Greenspan ; Subashan Perera ; Robert Recker ; Julie M. Wagner ; Parmatma Greeley ; Bryon R. Gomberg ; Pamela Seaman ; Michael Kleerekoper
• 关键词：Trabecular microarchitecture ; High resolution MRI ; Bisphosphonate therapy ; Osteoporosis
• 刊名：Bone
• 出版年：2010
• 出版时间：April 2010
• 年：2010
• 卷：46
• 期：4
• 页码：1006-1010
• 全文大小：301 K

文摘

lass=""h4"">Purpose

In addition to bone mineral density (BMD), trabecular microstructure contributes to skeletal strength. Our goal was to examine changes in trabecular microstructure in women on therapy.

lass=""h4"">Materials and methods

We followed 10 postmenopausal women receiving a bisphosphonate, risedronate (35 mg once weekly), over 12 months and examined trabecular microarchitecture with high resolution wrist MR images (hr-MRI). MRI parameters included bone volume/total volume (BV/TV), surface density (representing plates), curve density (representing rods), surface-to-curve ratio and erosion index (depicting deterioration). We assessed BMD of the spine, hip and radius and markers of bone turnover.

lass=""h4"">Results

Women had been receiving bisphosphonate therapy for 43 ± 9 months (mean ± SD) prior to the first MRI. Indices of hr-MRI demonstrated improvement in surface-to-curve ratio (13.0 % ) and a decrease in erosion index (12.1 % ) consistent with less deterioration (both p < 0.05). BMD of the spine, hip and radius and markers of bone turnover remained stable. Parameters of hr-MRI were associated with 1/3 distal radius BMD (correlation coefficient 0.71 to 0.86, p < 0.05).

lass=""h4"">Discussion

We conclude that hr-MRI of the radius demonstrates improvements in trabecular microstructure not appreciated by conventional BMD and provides additional information on parameters that contribute to structural integrity in patients on antiresorptive therapy.