ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target
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- 作者：Peter T. Nelsona ; b ; pnels2@email.uky.edu" class="auth_mail" title="E-mail the corresponding author ; Gregory A. Jichaa ; c ; Wang-Xia Wanga ; Eseosa Ighodaroa ; Sergey Artiushina ; Colin G. Nicholsd ; David W. Fardoa ; e
- 关键词：SUR2A ; SUR2B ; SUR2Ab ; SUR1 ; Neuropathology ; GWAS ; Hippocampus ; Oldest-old ; Arteriolosclerosis ; ABCC8
- 刊名：Ageing Research Reviews
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：24
- 期：part_PB
- 页码：111-125
- 全文大小：2958 K
文摘
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ABCC9 encodes SUR2, a metabolic sensor protein that has been shown to change (expression and function) in aging.
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ABCC9 is also strongly implicated in vasoregulation.
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ABCC9 has been implicated in neurologic diseases including sleep, depression, and hippocampal sclerosis of aging (HS-Aging).
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HS-Aging is a prevalent and impactful brain disease of advanced old age.
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ABCC9/SUR2 is a potentially druggable target that may provide a future therapeutic strategy.