Only 24% of macroscopically normal appendices during laparoscopy for acute lower abdominal pain are histologically normal.
The majority of normal-looking appendices showed a catarrhal inflammation without serosa involvement at histology.
A 2% of the innocent appendices showed a neuroendocrine tumor leading the patients to receive further treatments.
Appendectomy should be performed in all diagnostic laparoscopies for acute lower abdominal pain showing a normal appendix.