Validating Imaging Biomarkers of Cerebral Edema in Patients With Severe Ischemic Stroke

详细信息    查看全文

• 作者：Albert J. Yoo ; Kevin N. Sheth ; W. Taylor Kimberly ; Zeshan A. Chaudhry ; Jordan J. Elm ; Sven Jacobson ; Stephen M. Davis ; Geoffrey A. Donnan ; Gregory W. Albers ; Barney J. Stern ; R. Gilberto Gonz¨¢lez
• 关键词：Acute ischemic stroke ; biomarker subject codes 44 and 45 ; cerebral edema ; magnetic resonance imaging ; malignant stroke
• 刊名：Journal of Stroke and Cerebrovascular Diseases
• 出版年：2013
• 出版时间：August, 2013
• 年：2013
• 卷：22
• 期：6
• 页码：742-749
• 全文大小：637 K

文摘

| Figures/TablesFigures/Tables | ReferencesReferences

Background

There is no validated neuroimaging marker for quantifying brain edema.?We sought to test whether magnetic resonance imaging (MRI)-based metrics would reliably change during the early subacute period in a manner consistent with edema and whether they would correlate with relevant clinical endpoints.

Methods

Serial MRI studies from patients in the Echoplanar Imaging Thrombolytic Evaluation Trial with initial diffusion-weighted imaging (DWI) lesion volume >82 cm³ were analyzed. Two independent readers outlined the hemisphere and lateral ventricle on the involved side and calculated respective volumes at baseline and days 3 to 5. We assessed interrater agreement, volume change between scans, and the association of volume change with early neurologic deterioration (National Institutes of Health Stroke Scale score worsening of ¡Ý4 points), a 90-day modified Rankin scale (mRS) score of 0 to 4, and mortality.

Results

Of 12 patients who met study criteria, average baseline and follow-up DWI lesion size was 138 cm³ and 234 cm³, respectively. The mean time to follow-up MRI was 62 hours. Concordance correlation coefficients between readers were >0.90 for both hemisphere and ventricle volume assessment. Mean percent hemisphere volume increase was 16.2 ¡À 8.3 % (P < .0001), and the mean percent ventricle volume decrease was 45.6 ¡À 16.9 % (P < .001). Percent hemisphere growth predicted early neurologic deterioration (area under the curve [AUC] 0.92; P = .0005) and 90-day mRS 0 to 4 (AUC 0.80; P = .02).

Conclusions

In this exploratory analysis of severe ischemic stroke patients, statistically significant changes in hemisphere and ventricular volumes within the first week are consistent with expected changes of cerebral edema. MRI-based analysis of hemisphere growth appears to be a suitable biomarker for edema formation.