Predictive value of neutrophil-to-lymphocyte ratio in diabetic wound healing

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• 作者：Nasibeh Vatankhah ; MD^a ; ^{vatankha@ohsu.edu} ; Younes Jahangiri ; MD^b ; Gregory J. Landry ; MD^a ; Robert B. McLafferty ; MD^a ; Nabil J. Alkayed ; MD ; PhD^c ; Gregory L. Moneta ; MD^a ; Amir F. Azarbal ; MD^a
• 刊名：Journal of Vascular Surgery
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：65
• 期：2
• 页码：478-483
• 全文大小：436 K
• 卷排序：65

文摘

The neutrophil-to-lymphocyte ratio (NLR) has been used as a surrogate marker of systemic inflammation. We sought to investigate the association between NLR and wound healing in diabetic wounds.MethodsThe outcomes of 120 diabetic foot ulcers in 101 patients referred from August 2011 to December 2014 were examined retrospectively. Demographic, patient-specific, and wound-specific variables as well as NLR at baseline visit were assessed. Outcomes were classified as ulcer healing, minor amputation, major amputation, and chronic ulcer.ResultsThe subjects' mean age was 59.4 ± 13.0 years, and 67 (66%) were male. Final outcome was complete healing in 24 ulcers (20%), minor amputation in 58 (48%) and major amputation in 16 (13%), and 22 chronic ulcers (18%) at the last follow-up (median follow-up time, 6.8 months). In multivariate analysis, higher NLR (odds ratio, 13.61; P = .01) was associated with higher odds of nonhealing.ConclusionsNLR can predict odds of complete healing in diabetic foot ulcers independent of wound infection and other factors.