Enduring effects of early lead exposure: evidence for a specific deficit in associative ability
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Long–Evans dams were exposed to Pb acetate in the drinking water during both gestation and lactation, or lactation only. This report presents the results of an automated, olfactory, serial reversal task administered to the adult offspring. Although overall learning rate was not significantly affected by Pb exposure, analyses of specific phases of the learning process revealed that all three exposed groups required significantly more trials than controls to reach criterion from the point at which perseverative responding to the previously correct cue ended. These in-depth analyses revealed that the reversal learning impairment of the Pb-exposed animals was not due to a deficit in inhibiting responses to the previously correct cue, the mechanism commonly assumed to underlie impaired reversal learning. Instead, the analyses revealed that two other independent Pb effects were responsible for the prolonged postperseverative learning period: a response bias and an impaired ability to associate cues and/or actions with affective consequences. The contribution of these two factors varied as a function of the timing and intensity of the Pb exposure. It is hypothesized that the Pb-induced associative deficit may reflect lasting damage to the amygdala and/or nucleus accumbens, which comprise a system thought to modulate the process by which environmental cues acquire affective significance. h=""100"" bgcolor=""#F0F0F0"" valign=""top""> Publisher: h=""470"" valign=""top""> Elsevier Science h=""100"" bgcolor=""#F0F0F0"" valign=""top""> Language of Publication: h=""470"" valign=""top""> English h=""100"" bgcolor=""#F0F0F0"" valign=""top""> Item Identifier: h=""470"" valign=""top""> S0892-0362(99)00057-4 h=""100"" bgcolor=""#F0F0F0"" valign=""top""> Publication Type: h=""470"" valign=""top""> Article h=""100"" bgcolor=""#F0F0F0"" valign=""top""> ISSN: h=""470"" valign=""top""> 0892-0362 h=""100"" bgcolor=""#F0F0F0"" valign=""top""> Cited by: h=""470"" valign=""top"">
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h=""30""> <hr size=""1""/> Footnotes:

  1. Current address: Department of Psychology, Western Illinois University, Macomb, IL.

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