Vagus Nerve Stimulation for Electrographic Status Epilepticus in Slow-Wave Sleep

详细信息    查看全文

• 作者：Christopher M. Carosella ; MD^a ; Hansel M. Greiner ; MD^a ; Anna W. Byars ; PhD^a ; Todd M. Arthur ; MD^a ; James L. Leach ; MD^b ; Michele Turner ; CNP^a ; Katherine D. Holland ; MD ; PhD^a ; Francesco T. Mangano ; DO^c ; Ravindra Arya ; MD ; DM^a ; ^{Ravindra.Arya@cchmc.org" class="auth_mail" title="E-mail the corresponding author}
• 关键词：electrographic status epilepticus in slow sleep ; continuous spike and waves during slow-wave sleep (CSWS) ; vagus nerve stimulation (VNS) ; epilepsy surgery
• 刊名：Pediatric Neurology
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：60
• 期：Complete
• 页码：66-70
• 全文大小：1628 K

文摘

Electrographic status epilepticus in slow sleep or continuous spike and waves during slow-wave sleep is an epileptic encephalopathy characterized by seizures, neurocognitive regression, and significant activation of epileptiform discharges during nonrapid eye movement sleep. There is no consensus on the diagnostic criteria and evidence-based optimal treatment algorithm for children with electrographic status epilepticus in slow sleep.

Patient Description

We describe a 12-year-old girl with drug-resistant electrographic status epilepticus in slow wave sleep that was successfully treated with vagus nerve stimulation. Her clinical presentation, presurgical evaluation, decision-making, and course after vagus nerve stimulator implantation are described in detail.

Findings

After vagus nerve stimulator implantation, the girl remained seizure free for more than a year, resolved the electrographic status epilepticus in slow sleep pattern on electroencephalography, and exhibited significant cognitive improvement.

Conclusion

Vagus nerve stimulation may be considered for electrographic status epilepticus in slow sleep.