Comparative study of depth–dose distributions for beams of light and heavy nuclei in tissue-like media

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• 作者：Igor Pshenichnov ; Igor Mishustin ; Walter Greiner
• 关键词：Ionizing-radiation therapy physics ; Proton ; neutron and heavier particle dosimetry ; theory and algorithms ; Monte Carlo applications
• 刊名：Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
• 出版年：2008
• 出版时间：April 2008
• 年：2008
• 卷：266
• 期：7
• 页码：1094-1098
• 全文大小：334 K

文摘

We study the energy deposition by beams of light and heavy nuclei in tissue-like media for their possible application in charged-particle cancer therapy. The depth–dose distributions for protons, ³He, ¹²C, ²⁰Ne and ⁵⁸Ni nuclei are calculated within a Monte Carlo model based on the GEANT4 toolkit. These distributions are compared with each other and with available experimental data. It is demonstrated that nuclear fragmentation reactions essentially reduce the peak-to-plateau ratio of the dose profiles for deeply penetrating energetic ions heavier than ³He. On the other hand, the shapes of depth–dose profiles for all projectiles up to ⁵⁸Ni were found similar at low penetration depths.