Association of status redox with demographic, clinical and imaging parameters in patients with Huntington's disease
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- 作者：Marisol Peñ ; a-Sá ; ncheza ; marisol.pena@infomed.sld.cu" class="auth_mail" title="E-mail the corresponding author ; Gretel Riveró ; n-Formentb ; gretel.riveron@infomed.sld.cu" class="auth_mail" title="E-mail the corresponding author ; Tatiana Zaldí ; var-Vaillanta ; tzv@infomed.sld.cu" class="auth_mail" title="E-mail the corresponding author ; Alexis Soto-Lavastidaa ; alexisl@infomed.sld.cu" class="auth_mail" title="E-mail the corresponding author ; Judith Borrero-Sá ; nchezc ; borrerojudith@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Gloria Lara-Ferná ; ndeza ; glara@infomed.sld.cu" class="auth_mail" title="E-mail the corresponding author ; Enrique M. Esteban-Herná ; ndeza ; eesteban@infomed.sld.cu" class="auth_mail" title="E-mail the corresponding author ; Zenaida Herná ; ndez-Dí ; aza ; zmhernandez@infomed.sld.cu" class="auth_mail" title="E-mail the corresponding author ; Alina Gonzá ; lez-Quevedoa ; aglez@infomed.sld.cu" class="auth_mail" title="E-mail the corresponding author ; Isabel Ferná ; ndez-Almiralla ; isabelfa@infomed.sld.cu" class="auth_mail" title="E-mail the corresponding author ; Claudia Pé ; rez-Ló ; pezb ; claudia@cngen.sld.cu" class="auth_mail" title="E-mail the corresponding author ; Yaisa Castillo-Casañ ; asb ; yaisa@cngen.sld.cu" class="auth_mail" title="E-mail the corresponding author ; Olivia Martí ; nez-Bonneb ; Amelia Cabrera-Riverob ; amelia@cngen.sld.cu" class="auth_mail" title="E-mail the corresponding author ; Leyenis Valdé ; s-Ramosb ; leyenis@cngen.sld.cu" class="auth_mail" title="E-mail the corresponding author ; Rosa Guerra-Badí ; aa ; rosaguerra@inn.sld.cu" class="auth_mail" title="E-mail the corresponding author ; Rebeca Ferná ; ndez-Carrieraa ; rebeca@infomed.sld.cu" class="auth_mail" title="E-mail the corresponding author ; Marí ; a Caridad Mené ; ndez-Sainza ; cary@infomed.sld.cu" class="auth_mail" title="E-mail the corresponding author ; Sergio Gonzá ; lez-Garcí ; aa ; sergiogg@infomed.sld.cu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Huntington's disease ; Oxidative stress ; Reductase glutathione ; Reduced glutathione ; Advanced oxidative protein products ; Age at symptom onset ; Motor scale ; Caudate atrophy
- 刊名：Clinical Biochemistry
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：48
- 期：18
- 页码：1258-1263
- 全文大小：776 K
文摘
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The relation between oxidative stress biomarkers and typical parameters found in patients with Huntington´s disease.
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Glutathione reductase activity could be a potential biomarker for symptom onset in asymptomatic gene carriers.
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Reduced glutathione could be useful in monitoring the progression of neurodegeneration as an expression of caudate atrophy.