Telomere Recognition and Assembly Mechanism of Mammalian Shelterin

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• 作者：Fabian Erdel¹ ; ⁴ ; Katja Kratz² ; ⁴ ; Smaranda Willcox³ ; Jack D. Griffith³ ; Eric C. Greene¹ ; ^{ecg2108@cumc.columbia.edu} ; Titia de Lange² ; ⁵ ; ^{delange@rockefeller.edu}
• 关键词：telomere ; shelterin ; TRF1 ; TRF2 ; Rap1 ; target search ; diffusion ; DNA curtains ; single-molecule imaging ; electron microscopy
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：18
• 期：1
• 页码：41-53
• 全文大小：4301 K
• 卷排序：18

文摘

Shelterin can exist as a complex in solution Shelterin can diffuse along DNA but is impeded by nucleosomes Shelterin rapidly locates telomeric repeats by a three-dimensional diffusive search Shelterin forms ternary complexes with single- and double-stranded telomeric DNA