Secretion of microvesicular miRNAs in cellular and organismal aging

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• 作者：Sylvia Weilner ; Elisabeth Schraml ; Heinz Redl ; Regina Grillari-Voglauer ; Johannes Grillari
• 关键词：ESCRT ; endosomal sorting complex required for transport ; ILV ; intraluminal vesicles ; miRNA ; microRNA ; mRNA ; messenger RNA ; MVB ; multivesicular bodies ; MSC ; mesenchymal stem cell ; PM ; plasma membrane ; Rab ; Ras-related in brain ; RISC ; RNA-induced silencing
• 刊名：Experimental Gerontology
• 出版年：2013
• 出版时间：July, 2013
• 年：2013
• 卷：48
• 期：7
• 页码：626-633
• 全文大小：374 K

文摘

Changes of factors circulating in the systemic environment during human aging have been investigated for a long time. Only recently however, miRNAs have been found to be secreted into the systemic and tissue environments where they are protected from RNAses by either carrier proteins or by being packaged into microvesicles. These miRNAs are then taken up by recipient cells, changing the cellular behavior by the classical miRNA induced silencing of target mRNAs. The origin of circulating miRNAs, however, is in most instances unclear, but senescent cells emerge as a possible source of such secreted miRNAs. Since differences in the circulating miRNAs have been found in a variety of age-associated diseases, and accumulation of senescent cells in the elderly emerges as a possible detrimental factor in aging, it is well conceivable that these miRNAs might contribute to the functional decline observed during aging of organisms.

Therefore, we here give an overview on current knowledge on microvesicular secretion of miRNAs, changes of the systemic and tissue environments during aging of cells and organisms. Finally, we summarize current knowledge on miRNAs that are found to be specific for age-associated diseases.