Preliminary effects of bupropion and the promoter region (HTTLPR) serotonin transporter (SLC6A4) polymorphism on smoking behavior in schizophrenia

详细信息    查看全文

• 作者：Boaz Bloch ; Alon Reshef ; Tamara Cohen ; Amos Tafla ; Samich Gathas ; Salomon Israel ; Inga Gritsenko ; Ilana Kremer ; Richard P. Ebstein
• 关键词：Schizophrenia ; Smoking ; Drug therapy ; Bupropion ; Serotonin transporter ; Polymorphism ; Pharmacogenomics
• 刊名：Psychiatry Research
• 出版年：2010
• 出版时间：30 January 2010
• 年：2010
• 卷：175
• 期：1-2
• 页码：38-42
• 全文大小：236 K

文摘

In the current study, we investigated how individual variants in the serotonin promoter gene, previously associated with smoking cessation and linked to anxiety-related personality traits, were associated with individual differences in responsiveness to bupropion and cognitive behavioral therapy (CBT) in a clinical population. We hypothesize that subjects with the long allele may be less responsive to treatment. Altogether 61 schizophrenic patients (46M, 15F) on stable neuroleptic medication were initially enrolled in a smoking reduction program (prospective, double-blind, placebo-controlled) including cognitive behavioral therapy plus placebo or CBT plus bupropion. Additionally, subjects were genotyped for a polymorphism in the serotonin transporter (SLC6A4). Thirty-two subjects (23M, 9F) completed a 14-week course of treatment. While both groups of subjects demonstrated significant reductions in smoking behavior due to CBT, subjects receiving bupropion did not show significant differences in smoking behavior when compared to placebo. In addition, analysis by SPSS repeated measures multivariate showed a significant sex by SLC6A4 genotype interaction on the number of cigarettes smoked. Only male subjects with at least one short promoter region allele (short/short and short/long combined) showed a reduction in cigarette consumption as a result of treatment. This study provides preliminary evidence of how polymorphisms in the serotonin transporter can be informative in predicting individual responses to smoking reduction therapy.