刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:22 January 2017
年:2017
卷:482
期:4
页码:658-664
全文大小:1364 K
卷排序:482
文摘
In type 1 diabetic mice, KOR is desensitized in the heart. Upregulation of GRK2 plays an essential role in cardiac KOR desensitization in diabetic mice. Inhibition of GRK2 is a novel and effective strategy to restore cardiac KOR sensitivity.