Corticotropin-releasing hormone: Mediator of vertebrate life stage transitions?
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- 作者：Yugo Watanabe y.watanabe@latrobe.edu.au" class="auth_mail" title="E-mail the corresponding author ; Sylvia V.H. Grommen s.grommen@latrobe.edu.au" class="auth_mail" title="E-mail the corresponding author ; Bert De Groef ; b.degroef@latrobe.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Corticosteroid ; Corticotropin-releasing hormone ; Metamorphosis ; Thyroid hormone ; Thyrotropin ; Vertebrate life stage transition
- 刊名：General and Comparative Endocrinology
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：228
- 期：Complete
- 页码：60-68
- 全文大小：1379 K
文摘
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Thyroid hormones and corticoid synergies are critical in many vertebrate life stage transitions.
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Corticoids affect the expression of deiodinases and thyroid hormone receptors.
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CRH has corticotropic and thyrotropic actions in nonmammalian vertebrates.
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CRH may regulate transitions, but only amphibian metamorphosis has been studied in detail.
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The available evidence suggests that CRH has lost its thyrotropic activity in mammals.