Pediatric malignant salivary gland tumors: 60 year follow up

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• 作者：Cara C. Cockerill ^{Cockerill.Cara@mayo.edu" class="auth_mail" title="E-mail the corresponding author} ; Brian C. Gross¹ ; ^{Briangross81@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Stephanie Contag ^{Wise.Stephanie@mayo.edu" class="auth_mail" title="E-mail the corresponding author} ; Sarah Rein ^{reinx046@umn.edu" class="auth_mail" title="E-mail the corresponding author} ; Eric J. Moore ^{Moore.Eric@mayo.edu" class="auth_mail" title="E-mail the corresponding author} ; Kerry D. Olsen ^{Olsen.Kerry@mayo.edu" class="auth_mail" title="E-mail the corresponding author} ; Laura J. Orvidas ; ^{Orvidas.Laura@mayo.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Pediatric ; Salivary gland ; Tumor ; Cancer ; Outcome
• 刊名：International Journal of Pediatric Otorhinolaryngology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：88
• 期：Complete
• 页码：1-6
• 全文大小：310 K

文摘

To evaluate the presentation, treatments and outcomes in pediatric patients with salivary gland malignancies.

d="absSec_2">Study design

d="abspara0015">Retrospective chart review (1950–2012), Prospective phone interview.

d="absSec_3">Methods

d="abspara0020">Patients ≤18 years old with a salivary gland malignancy treated at our institution were identified. Patients were also contacted by phone for a follow up survey.

d="absSec_4">Results

d="abspara0025">Fifty-six patients were identified. Tumor origin was 88% parotid (n = 49), 5% (n = 3) submandibular and 7% (n = 4) minor salivary glands. Time from onset of symptoms to diagnosis was over one year (mean = 14.4 years). Fifteen out of 52 patients with major gland malignancy had a locoregional recurrence and local recurrences were almost all after initial enucleation. Two of these patients died of disease (overall disease specific survival = 96%). Three out of 4 patients with minor gland malignancy had a local recurrence and two patients with high grade pathology developed metastases and died of their disease (overall survival = 50%). On long term follow up survey in 13 patients (25%), 100% reported normal facial movement and 54% described symptoms of Frey's syndrome, which is higher than other reported series in children. Recurrence was noted up to 45 years after initial treatment.

d="absSec_5">Conclusions

d="abspara0030">The majority of malignant pediatric salivary gland tumors are low grade and have excellent survival, especially if found at an early stage. Minor salivary gland malignancies, particularly high grade, have a worse prognosis. Long term mild Frey's syndrome can be expected in approximately half of patients. We advocate a need for long term follow up and increased awareness among providers to diagnose these patients earlier.