Postnatal exposure to PFOS, but not PBDE 99, disturb dopaminergic gene transcription in the mouse CNS
详细信息 查看全文
- 作者：Stefan Hallgren ; stefan.hallgren@ebc.uu.se" class="auth_mail" title="E-mail the corresponding author ; Henrik Viberg
- 关键词：Perfluorinated chemical repellants ; Brominated flame retardants ; Developmental neurotoxicology ; Dopaminergic system ; Brain growth spurt
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：41
- 期：Complete
- 页码：121-126
- 全文大小：934 K
文摘
- •
Neonatal PFOS exposure altered gene expression of cortical DRD5 after 24 h.
- •
Neonatal PFOS exposure altered gene expression of hippocampal TH after 24 h.
- •
Neonatal PFOS altered gene expression of hippocampal DRD2 and TH in adults.
- •
Changed DA transcription may account for reported changes in cognition caused by PFOS.
- •
Neonatal PBDE 99 had no effect on dopaminergic gene expression.