No evidence for oxidative stress in the cerebellar tissues or cells of juvenile male mice exposed via lactation to the 6 non-dioxin-like PCBs at levels below the regulatory safe limits for humans
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- 作者：Arpiné ; Ardzivian Elnara ; c ; arpine.elnar@hotmail.fr" class="auth_mail" title="E-mail the corresponding author ; arpine.el-nar@univ-lorraine.fr" class="auth_mail" title="E-mail the corresponding author ; Fré ; dé ; ric Desora ; c ; Sylvain Legayd ; Christophe Nemose ; Frances T. Yenb ; c ; Thierry Osterb ; c ; Torsten Bohnd ; Rachid Soulimania ; c
- 关键词：Non-dioxin-like polychlorinated biphenyls ; Lactational exposure ; Central nervous system ; Oxidative stress ; Development ; Neurons ; Glial cells
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：14 March 2016
- 年：2016
- 卷：245
- 期：Complete
- 页码：7-14
- 全文大小：808 K
文摘
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We exposed dam mice to ∑6 NDL-PCBs (0, 1, 10 and 100 ng/kg b.w./day; PNDs 0–14).
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Oxidative status was evaluated in the cerebellum of PCB lactationally exposed pups at PND 14.
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No differences in ROS production, oxidative stress-related gene expressions or protein levels were shown between groups.
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Lactational exposure to ∑6 NDL-PCBs did not induce an oxidative damage in male mice at brain growth spurt.