GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution
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- 作者：Melis Karaca1 ; Francesca Frigerio1 ; Stephanie Migrenne2 ; Juliette Martin-Levilain1 ; Dorte M. Skytt3 ; Kamilla Pajecka3 ; Rafael Martin-del-Rio4 ; Rolf Gruetter5 ; Jorge Tamarit-Rodriguez4 ; Helle S. Waagepetersen3 ; Christophe Magnan2 ; Pierre Maechler1 ; pierre.maechler@unige.ch" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：13 October 2015
- 年：2015
- 卷：13
- 期：2
- 页码：365-375
- 全文大小：2222 K
文摘
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Glutamate is an energy substrate through GDH activity in the brain
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Central GDH deficit increases hypothalamic ADP/ATP ratios and activates AMPK
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Lack of glutamate utilization is compensated by increased brain glucose usage
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Lack of central glutamate consumption reshapes energy stores in periphery