Oxidative modification of blood serum proteins in multiple sclerosis after interferon or mitoxantrone treatment

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• 作者：Izabela Sadowska-Bartosz ; Monika Adamczyk-Sowa ; Agnieszka Gajewska ; Grzegorz Bartosz
• 关键词：Multiple sclerosis ; Oxidative protein modifications ; Carbonyl groups ; AGEs ; Thioredoxin ; Mitoxantrone
• 刊名：Journal of Neuroimmunology
• 出版年：15 January, 2014
• 年：2014
• 卷：266
• 期：1-2
• 页码：67-74
• 全文大小：757 K

文摘

This study was aimed at (i) comparison of the usefulness of serum protein oxidation parameters for assessment of oxidative stress (OS) in multiple sclerosis (MS), and (ii) comparison of OS in MS patients subject to various therapies. Elevated glycophore level was noted in relapsing-remitting (RRMS) patients without treatment and patients treated with interferons 尾1a and 尾1b (10.33 卤 3.27, 8.02 卤 2.22 and 8.56 卤 2.45 vs control 5.27 卤 0.73 fluorescence units (FU)/mg protein). Advanced oxidation protein products (295 卤 135 vs 83 卤 65 nmol/mg protein), carbonyl groups (3.68 卤 1.44 nmol/mg protein vs 2.03 卤 0.23 nmol/mg protein), kynurenine (7.71 卤 0.1.67 vs 5.5 卤 0.63 FU/mg protein) and N鈥?formylkynurenine (7.69 卤 0.7 vs 4.97 卤 0.59 FU/mg protein) levels were increased, while thioredoxin level was decreased in RRMS patients without treatment (5.03 卤 2.18 vs 10.83 卤 2.75 ng/ml) with respect to control. The level of OS was higher in untreated RRMS patients and in SPMS patients treated with mitoxantrone than in patients treated with interferon.