The pathogenesis of osteopenia in glycogen storage disease type III (GSDIII) is still unclear
Several endocrine and metabolic factors are known to affect BMD as well as physical activity
We found reduced levels of IGF-1, IGF-1/IGFBP3 molar ratio, insulin, calcitonin and osteocalcin and increased serum levels of CTX
DXA Z-score correlated inversely with cholesterol and triglycerides levels and directly with IGF-1/IGFBP3 molar ratio
Results shed light on possible factors leading to osteopenia and may be relevant in the management of GSDIII patients