Lack of GSK3β activation and modulation of synaptic plasticity by dopamine in 5-HT1A-receptor KO mice

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• 作者：C.N.J. Meunier¹ ; J.-M. Cancela ; P. Fossier ; ^{philippe.fossier@u-psud.fr}
• 关键词：Dopamine ; Electrophysiology ; Glycogen synthase kinase 3 ; Prefrontal cortex ; Pyramidal neurons ; Serotonin
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：124-136
• 全文大小：1967 K
• 卷排序：113

文摘

A new link between D2R and 5-HT1AR in regulating the E-I balance and the plasticity. Functional 5-HT1ARs are needed to allow the “classic” effect of D2R on plasticity. Loss of GSK3β signaling recruitment by D2Rs when 5-HT1ARs are absent. Dopamine action could be impaired in human pathologies linked to 5-HT1ARs depletion.