Interactions between CYP2E1, GSTZ1 and GSTT1 polymorphisms and exposure to drinking water trihalomethanes and their association with semen quality
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- 作者：Pan Yanga ; b ; Qiang Zenga ; b ; 1 ; qiangzeng506@163.com" class="auth_mail" title="E-mail the corresponding author ; Wen-Cheng Caoc ; Yi-Xin Wanga ; b ; Zhen Huanga ; b ; Jin Lia ; b ; Chong Liua ; b ; Wen-Qing Lua ; b ; 1 ; luwq@mails.tjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Disinfection by-products ; GSTT1 ; GSTZ1 ; CYP2E1 ; Exposure ; Semen quality
- 刊名：Environmental Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：147
- 期：Complete
- 页码：445-452
- 全文大小：648 K
文摘
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We used blood THM levels to estimate individual exposure.
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CYP2E1 and GSTZ1 variants were associated with decreased semen quality.
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CYP2E1 variants associated with higher blood TCM and TTHM.
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GSTT1 variants may modify the Br-THM exposure relation with semen quality.