文摘
The association between polymorphisms of glutathione S-transferase Z1 (GSTZ1) and susceptibility to bipolar disorder (BPD) is investigated. This study was performed on 228 BPD patients and 234 control subjects. Among early-onset patients, the variant alleles of Glu32Lys and G-1002A increased BPD susceptibility. The haplotype ¡°-1002 G, 32Glu, 42Gly¡± versus the other haplotypes was significantly decreased among early-onset patients compared to controls (P = 0.016).