Association between three genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1) and susceptibility to bipolar disorder

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• 作者：Zahra Rezaei ; Iraj Saadat ; Mostafa Saadat
• 关键词：Bipolar disorder ; GSTZ1 ; Haplotype
• 刊名：Psychiatry Research
• 出版年：2012
• 出版时间：30 June, 2012
• 年：2012
• 卷：198
• 期：1
• 页码：166-168
• 全文大小：132 K

文摘

The association between polymorphisms of glutathione S-transferase Z1 (GSTZ1) and susceptibility to bipolar disorder (BPD) is investigated. This study was performed on 228 BPD patients and 234 control subjects. Among early-onset patients, the variant alleles of Glu32Lys and G-1002A increased BPD susceptibility. The haplotype ¡°-1002 G, 32Glu, 42Gly¡± versus the other haplotypes was significantly decreased among early-onset patients compared to controls (P = 0.016).