Activation of GPR30 stimulates GTP-binding of Gαi1 protein to sustain activation of Erk1/2 in inhibition of prostate cancer cell growth and modulates metastatic properties

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• 作者：Kin-Mang Lau^a ; ^{kmlau@cuhk.edu.hk} ; Fanny Man-Ting Ma^a ; Jenny Tian Xia^a ; Queeny Kwan Yi Chan^a ; Chi-Fai Ng^b ; Ka-Fai To^a ; ^{kfto@cuhk.edu.hk}
• 关键词：GPR30 ; G protein-coupled receptor 30 ; Gαi1 ; Guanine Nucleotide Binding Protein (G Protein) Alpha Inhibiting Activity Polypeptide 1 ; Gαs ; Guanine Nucleotide Binding Protein (G Protein) Alpha Stimulating Activity Polypeptide 1 ; G-1 ; (± ; )-1-[(3aR* ; 4S* ; 9bS*)-4-(6-Bromo-1 ; 3-benzodioxol-5-yl)-3a ; 4 ; 5 ; 9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]-ethanone ; Erk1/2 ; extracellular signal-regulated kinases ; RACGAP1 ; Rac GTPase Activating Protein 1
• 刊名：Experimental Cell Research
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：350
• 期：1
• 页码：199-209
• 全文大小：1767 K
• 卷排序：350

文摘

GPR30 activation by G-1 activates Gαi1 to sustain Erk1/2 activation in PCa cells. Stimulations of AC-cAMP-PKA signaling block the G-1-induced cell growth inhibition. Molecular consequences of GPR30 activation by G-1 in PCa cells are demonstrated. Roles of GPR30 in controlling metastatic properties of PCa cells are revealed.