Allergic sensitization modifies the pulmonary expression of 5-hydroxytryptamine receptors in guinea pigs
详细信息 查看全文
- 作者：Guadalupe Có ; rdoba-Rodrí ; gueza ; Mario H. Vargasa ; Ví ; ctor Ruizb ; Veró ; nica Carbajala ; Patricia Campos-Bedollac ; Paulina Mercadillo-Herrerad ; José ; Luis Arreola-Ramí ; reza ; Patricia Segura-Medinaa ; psegura@unam.mx" class="auth_mail" title="E-mail the corresponding author ; psegura@iner.gob.mx" class="auth_mail" title="E-mail the corresponding author
- 关键词：Guinea pig ; 5-HT receptors ; Serotonin receptors ; Allergic sensitization ; Asthma model
- 刊名：Respiratory Physiology & Neurobiology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：223
- 期：Complete
- 页码：9-15
- 全文大小：573 K
文摘
- •
There is mounting evidence that 5-hydroxytryptamine (5-HT) plays a role in asthma.
- •
Major 5-HT receptor subtypes are constitutively expressed in the guinea pig lung.
- •
Allergic sensitization modifies the expression of 5-HT2A, 5-HT4 and 5-HT7 receptors.
- •
The role of 5-HT in the pathogenesis of asthma might lead to novel promising therapeutic approaches in the treatment of allergic airway diseases.