Guaianolides and elemanolides from Vernonia anthelmintica

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• 作者：Li Zhang ; Yong-Liang Shao ; Lei Hua ; Ya Li ; Syed Hamid Hussain ; Mohammad Arfan ; Kun Gao
• 关键词：Vernonia anthelmintica ; Guaianolides ; Elemanolides ; Cytotoxicity ; Biosynthetic relationships
• 刊名：Phytochemistry Letters
• 出版年：February, 2014
• 年：2014
• 卷：7
• 期：Complete
• 页码：14-18
• 全文大小：597 K

文摘

Two new guaianolides, (1R,4R,5S,6R,7R,8S)-8,15-dihydroxyguaia-10(14),11(13)-dien-12,6-olide (1) and (1R,4R,5S,6R,7R,8S,11S)-8,15-dihydroxyguaia-10(14)-en-6,12-olide (2), and two known elemanolides, (4S,5R,6R,7R,8S,10R,11S)-11,13-dihydrovernolepin (3) and (5R,6R,7R,8S,10R,11S)-melitensin (4) were isolated from the aerial parts of Vernonia anthelmintica Willd. The structures of these compounds were determined on the basis of IR, UV, MS, 1D-NMR and 2D-NMR, and their absolute configurations were deduced using the CD exciton chirality method and single-crystal X-ray diffraction. The possible biosynthetic relationships of compounds 1-4 are postulated. Compounds 1-4 were evaluated for their cytotoxicity against HL-60 and SMMC-7721 cell lines.