Celiac disease A diagnostic challenge with many facets

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• 作者：Guandalini ; Stefano ; Gupta ; Puneet
• 关键词：AGA ; antigliadin antibodies ; CD ; celiac disease ; ELISA ; enzyme linked immunosorbent assay ; EMA ; antiendomysium antibody ; ESPGHAN ; European society of pediatric gastroenterology ; hepatology ; and nutrition ; GFD ; gluten-free diet ; IEL ; intraepithelial lympho
• 刊名：Clinical and Applied Immunology Reviews
• 出版年：2002
• 出版时间：October - December, 2002
• 年：2002
• 卷：2
• 期：6
• 页码：293-305
• 全文大小：137 K

文摘

Celiac disease (CD) is an enteropathy occurring in genetically susceptible individuals with HLA DQ2 or DQ8 heterodimer caused by ingestion of certain cereals. Until recently it was generally believed that CD is a rare disorder in the United States. More recently, a screening with antiendomysium antibody (EMA) in healthy blood donors in the United States found the prevalence of EMA-positive individuals to be one in 250. The classical form of CD presents with gastrointestinal symptoms between 6 and 18 months of age. Recent studies have shown that almost 50 % of patients with newly diagnosed CD do not present with gastrointestinal symptoms