β-Carotene synergistically enhances the anti-tumor effect of 5-fluorouracil on esophageal squamous cell carcinoma in vivo and in vitro
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- 作者：Yanting Zhanga ; b ; 1 ; Xiangzhan Zhub ; 1 ; Tuanjie Huangb ; Lei Chena ; Yanxia Liub ; Qinghua Lib ; Jishi Songb ; Shanshan Mab ; Kun Zhangb ; Bo Yanga ; yangbo96@126.com" class="auth_mail" title="E-mail the corresponding author ; Fangxia Guana ; b ; guanfangxia@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-FU ; 5-fluorouracil ; ESCC ; esophageal squamous cell carcinoma ; THF ; tetrahydrofuran ; CCK-8 ; 2-(2-4-nitro phenyl methoxy-) 3-(4-nitro phenyl)-5-(2 ; 4-disulfonic acid benzene)-2 ; h-tetrazolium monosodium salt ; EdU ; 5-ethynyl-2&prime ; -deoxyuridine ; PBS ; phosphate buffered saline ; PI ; propidium iodide ; PVDF ; polyvinylidenedifluoride ; FBS ; fetal bovine serum ; BCA ; bicinchoninic acid ; FITC ; fluorescein isothiocyanate ; TUNEL ; terminal-deoxynucleoitidyl transferase mediated nick end labeling ; PCNA
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：2 November 2016
- 年：2016
- 卷：261
- 期：Complete
- 页码：49-58
- 全文大小：3310 K
文摘
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5-FU combined with β-carotene synergistically suppress ESCC cell proliferation.
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5-FU and β-carotene decreases the activity of AKT/mTOR/p70S6K pathway.
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β-Carotene enhances the anti-tumor effect of 5-FU on Eca109 xenograft tumors.