Antitumor and immunomodulatory activity of a water-soluble polysaccharide from Grifola frondosa
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- 作者：Guang-Hua Maoa ; 1 ; Yi Renb ; 1 ; Wei-Wei Fengc ; Qian Lic ; Hui-Yu Wud ; Dun jinb ; Ting Zhaob ; Cai-Quan Xue ; Liu-Qing Yangb ; yangliuqing@ujs.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xiang-Yang Wua ; wuxy@ujs.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Grifola frondosa ; Polysaccharide ; RAW264.7 cells ; Toll-like receptor (TLR) ; Tumoricidal activity
- 刊名：Carbohydrate Polymers
- 出版年：2015
- 出版时间：10 December 2015
- 年：2015
- 卷：134
- 期：Complete
- 页码：406-412
- 全文大小：1484 K
文摘
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GP11 is composed of mannose, glucose and galactose in a molar ratio of 1:5.04:2.61.
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GP11 significantly inhibits the growth of Heps tumor in vivo with no toxic.
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GP11 exhibits its antitumor activity by improving immune system functions.
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GP11 could up-regulate the expression of protein and gene via TLR-4 receptor.