Biological characteristics of different epidemic enterovirus 71 strains and their pathogeneses in neonatal mice and rhesus monkeys
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- 作者：Xie Zhongping ; Li Hua ; Yang Ting ; Liu Zhengling ; Feng Min ; Xie Tianhong ; Long Runxiang ; Shen Dong ; Jiang Guangju ; Yue Lei ; Yang Rong ; Luo Fangyu ; Li Qihan ; imbcams.lq@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hand ; Foot and mouth disease (HFMD) ; Enterovirus 71 (EV71) ; Animal models
- 刊名：Virus Research
- 出版年：2016
- 出版时间：2 February 2016
- 年：2016
- 卷：213
- 期：Complete
- 页码：82-89
- 全文大小：3631 K
文摘
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We investigated the pathogenic characteristics of 19 EV71 clinical isolates.
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Only 3 isolates were pathogenic in neonatal ICR mice and rhesus monkeys.
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The pathogenicity was dependent on the viral passages and approaches to infection.
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Age of subject animals was related to the susceptibility to EV71.