Interactive effects of selected pharmaceutical mixtures on bioaccumulation and biochemical status in crucian carp (Carassius auratus)
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- 作者：Jiannan Ding ; Guanghua Lu ; ghlu@hhu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yi Li
- 关键词：Pharmaceutical ; Mixture ; Interaction ; Carassius auratus ; Bioaccumulation ; Biomarker
- 刊名：Chemosphere
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：148
- 期：Complete
- 页码：21-31
- 全文大小：1174 K
文摘
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Crucian carp was exposed to three pharmaceuticals alone and in binary combination.
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Addition of FLU increased ROX and PRP accumulation in liver of crucian carp.
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FLU inhibited metabolism response to ROX and PRP at catalytic and mRNA levels.
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ROX + FLU and PRP + FLU treatments induced higher oxidative stress than sole chemical.