Nek2A phosphorylates and stabilizes SuFu: A new strategy of Gli2/Hedgehog signaling regulatory mechanism
详细信息 查看全文
- 作者：Yao Wanga ; e ; 1 ; Yong Lia ; 1 ; Guanghui Hua ; e ; Xuan Huanga ; Hai Raob ; Xiangyang Xiongc ; Zhijun Luoc ; Quqin Lud ; Shiwen Luoa ; e ; shiwenluo@ncu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：NIMA-related expressed kinase 2A ; Suppressor of fused ; Phosphorylation ; Transcription factor Gli2 ; Hedgehog signaling pathway
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：28
- 期：9
- 页码：1304-1313
- 全文大小：1532 K
文摘
- listitem" id="list_l0005">
- •
Nek2A interacts with and stabilizes SuFu protein.
- •
Nek2A promotes the phosphorylation of SuFu.
- •
Phosphorylated SuFu inhibits the nuclear localization and transcriptional activity of Gli2/Hh signaling.