Dexmedetomidine attenuates inflammatory reaction in the lung tissues of septic mice by activating cholinergic anti-inflammatory pathway
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- 作者：Zhaoguo Liu1 ; Yueping Wang1 ; Yaoqi Wang ; wangyaoqi2006@163.com" class="auth_mail" title="E-mail the corresponding author ; Qiaoqing Ning ; Yong Zhang ; Chunzhi Gong ; Wenxiang Zhao ; Guangjian Jing ; Qianqian Wang
- 关键词：Dexmedetomidine ; Lung ; Sepsis ; Cholinergic anti-inflammatory pathway ; Lipopolysaccharides
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：35
- 期：Complete
- 页码：210-216
- 全文大小：902 K
文摘
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Dexmedetomidine inhibits the TNF-α and IL-6 at both the mRNA and protein levels.
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α-Bungarotoxin reverses dexmedetomidine-induced decrease in NF-κBp65 activation.
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α-Bungarotoxin reverses the protective effects of dexmedetomidine on septic mice.
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Dexmedetomidine inhibits lung inflammatory through the cholinergic anti-inflammatory pathway.