Controlled mono- and double-Heck reaction catalyzed by a dicarbene dipalladium complex

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• 作者：Yunfei Li^a ; Gang Liu^a ; Changsheng Cao^a ; ; Shuzhan Wang^a ; Yuling Li^a ; Guangsheng Pang^b ; Yanhui Shi^a ; ^c ; ^{yhshi@jsnu.edu.cn}
• 关键词：Heck reaction ; N-heterocyclic carbene ; Palladium ; Dinuclear
• 刊名：Tetrahedron
• 出版年：2013
• 出版时间：29 July, 2013
• 年：2013
• 卷：69
• 期：30
• 页码：6241-6250
• 全文大小：3896 K

文摘

The phosphine-free mono- and double-Heck reaction of terminal olefins with electron-deficient and electron-rich aryl halides (iodides and bromides) is described. These reactions are catalyzed by the dicarbene dipalladium complex rong class=""boldFont"">1rong> by controlling the stoichiometry of the aryl halide and the olefine, the loading of the palladium catalyst, as well as using different base, and with or without additive. The procedure of double-Heck reaction allows ¦Â,¦Â-diarylation and ¦Â,¦Â¡ä-diarylation of terminal olefins and affords trisubstituted olefins in good to excellent yields.