Based on the advantages of adhesion preparations and the application status of microspheres in mucous delivery, this paper primarily reviews the bioadhesive microspheres via transmucosal administration routes, including the mucosa in alimentary tract and other lumens.
The detailed researches about of celladhesive microspheres and some new-style bioadhesive microspheres are mentioned.
This review attempts to reveal the advances of bioadhesive microspheres as cell-selective bioadhesion systems.
Mechanisms should be put under tight scrutiny and more attention should be focused on the excellent bioadhesive materials and the ‘second generation mucoadhesives’.
Meaningful clinical application of bioadhesive microspheres are also of current concerns and need more detailed researches.