A sensitive liquid chromatography-tandem mass spectrometry method for pharmacokinetics and tissue distribution of nuciferine in rats
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- 作者：Shengying Gu ; Guanhua Zhu ; Yuzhu Wang ; Qin Li ; Xin Wu ; Jigang Zhang ; Gaolin Liu ; gaolinliu@aliyun.com" class="auth_mail ; Xiaoyu Li ; xyljaylxb@163.com" class="auth_mail
- 关键词：Nuciferine ; LC&ndash ; MS/MS ; Pharmacokinetics ; Tissue distribution
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：15 June 2014
- 年：2014
- 卷：961
- 期：Complete
- 页码：20-28
- 全文大小：1483 K
文摘
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A novel LC–MS/MS method was developed and validated for the determination of nuciferine in rat plasma and tissue sample.
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The lower limit of quantification for nuciferine was 0.1 ng/ml in all biological fluids.
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Low absolute bioavailability of nuciferine was calculated after oral administration.
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The distribution of nuciferine in brain, liver and adipose tissue provided the material basis for pharmacological action of nuciferine.