Syndecan-4 shedding impairs macrovascular angiogenesis in diabetes mellitus
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- 作者：Ran Li ; Jun Xie ; Han Wu ; Guannan Li ; Jianzhou Chen ; Qinhua Chen ; Lian Wang ; Biao Xu ; xubiao@medmail.com.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Syndecan-4 ; Diabetes mellitus ; Shedding
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：20 May 2016
- 年：2016
- 卷：474
- 期：1
- 页码：15-21
- 全文大小：1341 K
文摘
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Synd4 shedding from endothelial cells is accelerated under the stimulation of AGEs.
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Extracellular domain of synd4 is diminished in the endothelium of DM rats.
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Aortic rings of synd4 null mice showed impaired angiogenesis.
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Overexpression of synd4 partly rescues macrovascular angiogenesis in db/db mice.